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33622 Conferences

Lyophilization Technology - Webinar By ComplianceOnline

Added by Referral on 2011-07-01

Conference Dates:

Start Date Start Date: 2011-07-07
Last Date Last Day: 2011-07-07
Deadline for abstracts/proposals Deadline for abstracts/proposals: 2011-07-07

Conference Contact Info:

Contact Person Contact Person: Referral
Email Email: referral@complianceonline.com
Address Address: 2600 E. Bayshore Road, Online Event, Palo Alto, CA, 94303, United States
Phone Tel: +1-650-620-3915
Phone Fax: +1-650-963-2556

Conference Description:

Why Should You Attend :

This seminar will begin with a discussion on freezing and annealing as part of a lyophilization cycle. It has been shown that how a sample is frozen prior to freeze-drying can have a dramatic impact on how that product dries during primary and secondary drying. Additionally, for large, biologically based molecules, the freezing segment of the cycle can have a large impact on the stability of those molecules as well.

After freezing, the discussion will turn to the primary and secondary drying processes, and how they are affected by the engineering principles of heat and mass transfer. Using the principles just presented, the discussion will turn to scale-up and cycle transfer issues, which have traditionally been some of the most challenging issues in getting a product up to a full-scale manufacturing process.

Finally the discussion will finish with several case studies in fail products due to poor formulations or poor lyophilization cycles. This will be an open discussion with the attendees to troubleshoot, diagnose, and correct failed batches of product.

Areas Covered in the Seminar :

- Freezing vs. vapor pressure
- Ice nucleation and ice crystal growth
- Effects of ice crystal particle size
- Eutectic and/or glass formation
- Annealing theory and techniques
- Heat transfer theory
- Mass transfer theory
- Conduction, convection, and radiation
- Critical parameters in scale-up and cycle transfer
- Scale-up strategy
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